What is the Mini-COTES study?

Mini-COTES is a research study being conducted by Sophia Vinogradov, M.D., Melissa Fisher, Ph.D, and Ian Ramsay, Ph.D., about how computerized training might help people with recent-onset schizophrenia lessen their symptoms and learn new thinking and problem-solving skills, and improve their overall quality of life.

Where is the COTES Study?

The COTES study will be run out of the University of Minnesota Physicians First Episode Psychosis Program in St. Louis Park, Minnesota. However, the participants assigned to the computer training conditions will complete these from their own homes.

Why Participate in Mini-COTES?

Although you may or may not directly benefit from participating in this research, the information that you provide will help health professionals better understand how computerized training might be used in the future to help people with schizophrenia lessen their symptoms and to learn new thinking skills and problem-solving abilities.

Altogether, you could receive up to $320 for participating in this study. You'll be paid up to $80 for completing the tests at the start of the study. After completing the training, you'll receive up to $120 for the next set of tests, and an additional $120 for the follow-up tests which will be completed 6 months later. Participants who are in one of the two computerized training groups can earn $25 for each 5 hours of training completed up to $150 (30 hours of training), for a total of $470.

What will happen if I decide to participate?

  • Research staff will interview you and give you some tests that include questions about your symptoms and how you are feeling, as well as some paper and pencil and computerized tests of your thinking skills.
  • You will be assigned by chance to either complete either one of two computer-based trainings at home or receive First Episode Psychosis Program services as usual for the next six weeks. If you are assigned to the computer-based training, you'll be asked to spend 60 minutes per day, five days per week, completing a computerized training program at home on a laptop the study staff will provide.
  • After six weeks, you'll complete another round of tests about your symptoms, your thinking skills, and how you are feeling.
  • You will be asked to return after another 6 moths for some follow-up tests.
  • If you were assigned to receive First Episode Psychosis Program services as usual, you will be offered the computerized training after completing the 6 month follow-up tests.

How long will the study take?

If you decide to participate in this study, you will be actively involved in the research study for approximately 10 weeks.

Tags: Psychosis

Study team

Principal Investigator (PI):
Study Coordinator:

Study status

Enrolling participants

Who can participate?

Study participants should:

  • Have a diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder, bipolar disorder with psychotic features, major depressive disorder with psychotic features, psychosis disorder not otherwise specified, or unspecified schizophrenia spectrum disorder
  • Have had their first psychotic episode within the last 2 years
  • Be in good general health
  • Be an outpatient (for at least 1 month)
  • Not currently be treated with benztropine, diphenhydramine, or high doses of clozapine (>500 mg po qd) or olanzapine (>20 mg).
  • Be fluent in written and spoken English (learned English before age 12)
  • Be between the ages of 18 and 35 years old
  • Be currently enrolled in First Episode Psychosis Program services and have reached the "stabilization" phase of treatment.

For more information:

Riley Capizzi, study coordinator

or email: