Single Dose Intranasal Oxytocin Study
This research is being done to better understand if the social, language, and cognitive thought processes of individuals with autism can become more flexible. We are looking into new treatment approaches such as intranasal oxytocin that may increase the brain's ability to learn by being less rigid and more flexible.
How long with the study last?
Participants will need to come to our research lab at the CNBD 2 times, about 2 weeks apart. In addition, you will receive a follow-up telephone call from the study coordinator within a week of each study visit. Each study visit will take approximately 3-4 hours.
What is involved in the study?
The use of intranasal oxytocin (Syntocinon) is investigational in this study. Participants will be receiving a single dose of the medication so that we may better understand how it acts on symptoms of autism.
Participants are randomly assigned by chance to receive either oxytocin or placebo (inactive substance) during the first study visit. At the second visit, the other substance is given.
During each study visit, participants will be given several tasks that involve problem solving, looking at images and making judgments about them, and listening to sounds and words and answering questions about them. These tests will measure mental abilities such as cognitive flexibility and social recognition. We will also record eye movement when they look at items presented on the computer screen, as well as take 4 samples of blood.
- Ages 10-17
- Diagnosed with autism spectrum disorder