Functional Connectivity Changes During Early Recovery as a Marker for Relapse

What is the study?

The study purpose is to examine whether there are structural or functional differences in the brains of individuals who use cocaine or amphetamines as opposed to control participants who have never used cocaine or amphetamines. More specifically, it will allow the investigator to see how the brain changes once people get sober and how those changes relate to successful recovery. This study will allow the investigator to examine the interaction between cocaine/amphetamines and impulsivity (meaning to act on impulse rather than thought). Results from this study will inform new biologically-based interventions to complement existing treatment programs, in the hope of leading the field in a new direction.

Who can participate?

We are actively enrolling SUD (stimulant use disorder) participants at our study partner sites who are currently undergoing treatment for stimulant use as their primary drug of choice. SUD participants should be within 3 to 7 weeks of their last use date at the time of study enrollment.

We are also enrolling a second group of HC (healthy control) participants who have never been treated for any drug or alcohol abuse.

All participants should be age 18 to 45, be available to complete all study visits and go through a phone screen with study staff.

Where is the study?

We conduct study visits at various treatment centers in Minneapolis and St. Paul and on campus. MRI visits are always done at the Center for Magnetic Resonance Research.

What will happen if I decide to participate?

Participants in the Substance Use Disorder group will:

  • Complete a diagnostic screening interview at baseline.
  • Complete questionnaires and computer tasks at baseline, 1 month and 2-month time points.
  • Complete MRI brain imaging data collection at the baseline, 1 month and 2-month time points.
  • Complete 9 follow-up phone calls to assess for relapse.

Participants in the Healthy Control group will:

  • Complete a diagnostic screening interview at baseline.
  • Complete questionnaires and computer tasks at baseline and 2-month time points.
  • Complete MRI brain imaging data collection at the baseline and 2-month time points.

Study team

Study status

Enrolling participants

Who can participate?

Adult individuals with substance use disorder and adult healthy control subjects

Contact: 

Melanie Stimac, study coordinator
stima011@umn.edu
612-301-2449